Fact: Brain surgery dates back to the stone age and was performed in many different civilizations around the world. Cutting holes in the skulls was probably meant to relieve pressure and release evil spirits. The patients may have had problems such as epilepsy, headaches or depression. Evidence of the skull healing skulls indicates that the some patients survived for a while after surgery. This type of brain surgery was called trepanning, and has made a surprising comeback in recent years.
Quote: Don't make us splatter your brains -- The Flintstones, the movie
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